@article{08bc62f0cd734854a3e6c240aca79e74,
title = "Local Axonal Conduction Shapes the Spatiotemporal Properties of Neural Sequences",
abstract = "Sequential activation of neurons has been observed during various behavioral and cognitive processes, but the underlying circuit mechanisms remain poorly understood. Here, we investigate premotor sequences in HVC (proper name) of the adult zebra finch forebrain that are central to the performance of the temporally precise courtship song. We use high-density silicon probes to measure song-related population activity, and we compare these observations with predictions from a range of network models. Our results support a circuit architecture in which heterogeneous delays between sequentially active neurons shape the spatiotemporal patterns of HVC premotor neuron activity. We gauge the impact of several delay sources, and we find the primary contributor to be slow conduction through axonal collaterals within HVC, which typically adds between 1 and 7.5 ms for each link within the sequence. Thus, local axonal “delay lines” can play an important role in determining the dynamical repertoire of neural circuits.",
author = "Robert Egger and Yevhen Tupikov and Margot Elmaleh and Katlowitz, {Kalman A.} and Benezra, {Sam E.} and Picardo, {Michel A.} and Felix Moll and J{\"o}rgen Kornfeld and Jin, {Dezhe Z.} and Long, {Michael A.}",
note = "Funding Information: We thank Dmitriy Aronov, Gy{\"o}rgy Buzs{\'a}ki, Dmitri Chklovskii, Yarden Cohen, Annegret Falkner, Dan Levenstein, Cengiz Pehlevan, Alex Reyes, John Rinzel, Richard Tsien, and members of the Long laboratory for comments on earlier versions of this manuscript. We thank the Fee laboratory for providing single-electrode extracellular recordings of HVC projection neurons and Marcel Oberlaender for the reconstructions of L4 neurons. We thank NYU Langone's Microscopy Laboratory for assistance with electron microscopy. We also acknowledge helpful conversations with Asohan Amarasingham, Yoram Burak, Dina Obeid, and Kanaka Rajan. This research was supported by the DFG (EG 401/1-1 to R.E.), NIH (R01 NS075044 to M.A.L.), NSF (EF-1822478 to D.Z.J. and M.A.L.), and Simons Global Brain (to M.A.L.). R.E. and M.A.L conceived the study and designed the experiments. M.E. S.E.B. M.A.L. M.A.P. F.M. and J.K. conducted the research. R.E. K.A.K. S.E.B. M.A.P. F.M. J.K. and M.A.L. performed data analyses. Y.T. R.E. M.A.L. and D.Z.J. developed the model. Y.T. performed simulations. R.E. and M.A.L. created the figures. R.E. wrote the initial draft of the manuscript. R.E. D.Z.J. and M.A.L. edited and reviewed the final manuscript. R.E. M.A.L. and D.Z.J. acquired funding. M.A.L. and D.Z.J. supervised the project. The authors declare no competing interests. Funding Information: We thank Dmitriy Aronov, Gy{\"o}rgy Buzs{\'a}ki, Dmitri Chklovskii, Yarden Cohen, Annegret Falkner, Dan Levenstein, Cengiz Pehlevan, Alex Reyes, John Rinzel, Richard Tsien, and members of the Long laboratory for comments on earlier versions of this manuscript. We thank the Fee laboratory for providing single-electrode extracellular recordings of HVC projection neurons and Marcel Oberlaender for the reconstructions of L4 neurons. We thank NYU Langone{\textquoteright}s Microscopy Laboratory for assistance with electron microscopy. We also acknowledge helpful conversations with Asohan Amarasingham, Yoram Burak, Dina Obeid, and Kanaka Rajan. This research was supported by the DFG ( EG 401/1-1 to R.E.), NIH ( R01 NS075044 to M.A.L.), NSF ( EF-1822478 to D.Z.J. and M.A.L.), and Simons Global Brain (to M.A.L.). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = oct,
day = "15",
doi = "10.1016/j.cell.2020.09.019",
language = "English (US)",
volume = "183",
pages = "537--548.e12",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}