TY - JOUR
T1 - Localization of Membrane‐Bound Catechol‐O‐Methyltransferase
AU - Rivett, A. Jennifer
AU - Francis, Andrew
AU - Roth, Jerome A.
PY - 1983/5
Y1 - 1983/5
N2 - Abstract: Previous studies of the distribution of catechol‐O‐methyltransferase (COMT) have concentrated on the soluble enzyme activity. In this study the activity of the membrane‐bound enzyme was determined in different brain regions and peripheral tissues of the rat. Membrane‐bound COMT, like the soluble enzyme, has a general distribution with high levels in liver, kidney, and vas deferens. However, the ratio of membrane‐bound to soluble activity varies almost 30‐fold in different tissues, with the highest ratio in brain. Membrane‐bound activity varies twofold within brain. In view of their different localization and kinetic properties, it seems likely that the two forms of COMT have different functions in vivo. 1983 International Society for Neurochemistry
AB - Abstract: Previous studies of the distribution of catechol‐O‐methyltransferase (COMT) have concentrated on the soluble enzyme activity. In this study the activity of the membrane‐bound enzyme was determined in different brain regions and peripheral tissues of the rat. Membrane‐bound COMT, like the soluble enzyme, has a general distribution with high levels in liver, kidney, and vas deferens. However, the ratio of membrane‐bound to soluble activity varies almost 30‐fold in different tissues, with the highest ratio in brain. Membrane‐bound activity varies twofold within brain. In view of their different localization and kinetic properties, it seems likely that the two forms of COMT have different functions in vivo. 1983 International Society for Neurochemistry
UR - http://www.scopus.com/inward/record.url?scp=0020637004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020637004&partnerID=8YFLogxK
U2 - 10.1111/j.1471-4159.1983.tb13597.x
DO - 10.1111/j.1471-4159.1983.tb13597.x
M3 - Article
C2 - 6834074
AN - SCOPUS:0020637004
SN - 0022-3042
VL - 40
SP - 1494
EP - 1496
JO - Journal of neurochemistry
JF - Journal of neurochemistry
IS - 5
ER -