Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization

Jia Xu; Ross C. Hardison

doi:10.1016/0888-7543(91)90265-G

Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization

Jia Xu, Ross C. Hardison

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome.

Original language	English (US)
Pages (from-to)	362-365
Number of pages	4
Journal	Genomics
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(91)90265-G
State	Published - Feb 1991

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/0888-7543(91)90265-G

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@article{de016c6c34ef465193fbce767edf0dd9,

title = "Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization",

abstract = "The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome.",

author = "Jia Xu and Hardison, {Ross C.}",

note = "Funding Information: We thank A. Clark for the computer program for analyzing tail probabilities for Poisson distributions, and C. Boyer and C. Gay for the use of their microscopes. This research is supported by PHS Grant DK17635 and an RCDA to R.C.H., DKOl589.",

year = "1991",

month = feb,

doi = "10.1016/0888-7543(91)90265-G",

language = "English (US)",

volume = "9",

pages = "362--365",

journal = "Genomics",

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T1 - Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization

AU - Xu, Jia

AU - Hardison, Ross C.

N1 - Funding Information: We thank A. Clark for the computer program for analyzing tail probabilities for Poisson distributions, and C. Boyer and C. Gay for the use of their microscopes. This research is supported by PHS Grant DK17635 and an RCDA to R.C.H., DKOl589.

PY - 1991/2

Y1 - 1991/2

N2 - The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome.

AB - The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome.

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JO - Genomics

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Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization

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