TY - GEN
T1 - Localized cell lysis by self focused acoustic transducers
AU - Zhu, J.
AU - Qiu, X.
AU - Oiler, J.
AU - Yu, C.
AU - Wang, Z.
AU - Lee, C.
AU - Hsiai, T. K.
AU - Kim, E. S.
AU - Yu, H.
PY - 2009
Y1 - 2009
N2 - This paper presents localized cell lysis using a Self Focused Acoustic Transducer (SFAT). The 18 MHz acoustic waves generated by the SFAT focus at a spot of around 100 μm in diameter with a peak intensity of 25 W/cm 2, which is strong enough to produce acoustic cavitation at such high frequency. With the great pressure and temperature produced by the cavitation, cells are broken and detached in a tiny area from the substrate while leaving other ones intact. That is ideal for localized cell lysis and killing tumors. Moreover, the gene analysis is conducted to confirm that the lysis effect is due to the high intensity of focused acoustic waves.
AB - This paper presents localized cell lysis using a Self Focused Acoustic Transducer (SFAT). The 18 MHz acoustic waves generated by the SFAT focus at a spot of around 100 μm in diameter with a peak intensity of 25 W/cm 2, which is strong enough to produce acoustic cavitation at such high frequency. With the great pressure and temperature produced by the cavitation, cells are broken and detached in a tiny area from the substrate while leaving other ones intact. That is ideal for localized cell lysis and killing tumors. Moreover, the gene analysis is conducted to confirm that the lysis effect is due to the high intensity of focused acoustic waves.
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U2 - 10.1109/SENSOR.2009.5285398
DO - 10.1109/SENSOR.2009.5285398
M3 - Conference contribution
AN - SCOPUS:71449112682
SN - 9781424441938
T3 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
SP - 608
EP - 611
BT - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
T2 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Y2 - 21 June 2009 through 25 June 2009
ER -