Localized hypertrophic neuropathy: Magnetic resonance imaging findings and long-term follow-up

Zachary Simmons, Ziad I. Mahadeen, Milind J. Kothari, Stephen Powers, Scott Wise, Javad Towfighi

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Four patients with painless, progressive focal neurological deficits that localized to peripheral nerve or plexus were eventually found to have the relatively rare condition of localized hypertrophic neuropathy or intraneural perineurioma. Magnetic resonance imaging (MRI) was an excellent tool for aiding in the precise localization of the lesion, if specifically tailored with regard to imaging planes and specific MRI sequences. Fat- saturated T2-weighted and fat-saturated T1-weighted postgadolinium images provided the best visualization, particularly with a high-field magnet and phase array body coil. Two patients stabilized following resection of the lesion and sural nerve grafting, and 1 had partial improvement in a proximal muscle following neurolysis.

Original languageEnglish (US)
Pages (from-to)28-36
Number of pages9
JournalMuscle and Nerve
Issue number1
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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