Localized targeted antiangiogenic drug delivery for glioblastoma

Gregory D. Arnone; Abhiraj D. Bhimani; Tania Aguilar; Ankit I. Mehta

doi:10.1007/s11060-018-2747-2

Localized targeted antiangiogenic drug delivery for glioblastoma

Gregory D. Arnone, Abhiraj D. Bhimani, Tania Aguilar, Ankit I. Mehta

Department of Neurosurgery

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future.

Original language	English (US)
Pages (from-to)	223-231
Number of pages	9
Journal	Journal of neuro-oncology
Volume	137
Issue number	2
DOIs	https://doi.org/10.1007/s11060-018-2747-2
State	Published - Apr 1 2018

All Science Journal Classification (ASJC) codes

Oncology
Neurology
Clinical Neurology
Cancer Research

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title = "Localized targeted antiangiogenic drug delivery for glioblastoma",

abstract = "Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future.",

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AU - Bhimani, Abhiraj D.

AU - Aguilar, Tania

AU - Mehta, Ankit I.

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N2 - Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future.

AB - Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future.

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Localized targeted antiangiogenic drug delivery for glioblastoma

Abstract

All Science Journal Classification (ASJC) codes

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