Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Antolin M. Llorente; Wilfred G. Van Gorp; Martin J. Stern; Lance George; Paul Satz; Thomas D. Marcotte; Gilbert M. Calvillo; Charles H. Hinkin

doi:10.1017/S1355617701711034

Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Antolin M. Llorente, Wilfred G. Van Gorp, Martin J. Stern, Lance George, Paul Satz, Thomas D. Marcotte, Gilbert M. Calvillo, Charles H. Hinkin

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.

Original language	English (US)
Pages (from-to)	27-32
Number of pages	6
Journal	Journal of the International Neuropsychological Society
Volume	7
Issue number	1
DOIs	https://doi.org/10.1017/S1355617701711034
State	Published - 2001

All Science Journal Classification (ASJC) codes

General Neuroscience
Clinical Psychology
Clinical Neurology
Psychiatry and Mental health

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10.1017/S1355617701711034

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Llorente, A. M., Van Gorp, W. G., Stern, M. J., George, L., Satz, P., Marcotte, T. D., Calvillo, G. M., & Hinkin, C. H. (2001). Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation. Journal of the International Neuropsychological Society, 7(1), 27-32. https://doi.org/10.1017/S1355617701711034

Llorente, Antolin M. ; Van Gorp, Wilfred G. ; Stern, Martin J. et al. / Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients : Results of a randomized, double-blind, placebo-controlled investigation. In: Journal of the International Neuropsychological Society. 2001 ; Vol. 7, No. 1. pp. 27-32.

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abstract = "This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.",

author = "Llorente, {Antolin M.} and {Van Gorp}, {Wilfred G.} and Stern, {Martin J.} and Lance George and Paul Satz and Marcotte, {Thomas D.} and Calvillo, {Gilbert M.} and Hinkin, {Charles H.}",

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Llorente, AM, Van Gorp, WG, Stern, MJ, George, L, Satz, P, Marcotte, TD, Calvillo, GM & Hinkin, CH 2001, 'Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation', Journal of the International Neuropsychological Society, vol. 7, no. 1, pp. 27-32. https://doi.org/10.1017/S1355617701711034

Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation. / Llorente, Antolin M.; Van Gorp, Wilfred G.; Stern, Martin J. et al.
In: Journal of the International Neuropsychological Society, Vol. 7, No. 1, 2001, p. 27-32.

Research output: Contribution to journal › Article › peer-review

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AU - Llorente, Antolin M.

AU - Van Gorp, Wilfred G.

AU - Stern, Martin J.

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AU - Satz, Paul

AU - Marcotte, Thomas D.

AU - Calvillo, Gilbert M.

AU - Hinkin, Charles H.

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AB - This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.

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Llorente AM, Van Gorp WG, Stern MJ, George L, Satz P, Marcotte TD et al. Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation. Journal of the International Neuropsychological Society. 2001;7(1):27-32. doi: 10.1017/S1355617701711034

Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Abstract

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