Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Antolin M. Llorente; Wilfred G. Van Gorp; Martin J. Stern; Lance George; Paul Satz; Thomas D. Marcotte; Gilbert M. Calvillo; Charles H. Hinkin

doi:10.1017/S1355617701711034

Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Antolin M. Llorente
, Wilfred G. Van Gorp
, Martin J. Stern
, Lance George
, Paul Satz
, Thomas D. Marcotte
, Gilbert M. Calvillo
, Charles H. Hinkin

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.

Original language	English (US)
Pages (from-to)	27-32
Number of pages	6
Journal	Journal of the International Neuropsychological Society
Volume	7
Issue number	1
DOIs	https://doi.org/10.1017/S1355617701711034
State	Published - 2001

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Neuroscience
Clinical Psychology
Clinical Neurology
Psychiatry and Mental health

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10.1017/S1355617701711034

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Llorente, A. M., Van Gorp, W. G., Stern, M. J., George, L., Satz, P., Marcotte, T. D., Calvillo, G. M., & Hinkin, C. H. (2001). Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation. Journal of the International Neuropsychological Society, 7(1), 27-32. https://doi.org/10.1017/S1355617701711034

Llorente, Antolin M. ; Van Gorp, Wilfred G. ; Stern, Martin J. et al. / Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients : Results of a randomized, double-blind, placebo-controlled investigation. In: Journal of the International Neuropsychological Society. 2001 ; Vol. 7, No. 1. pp. 27-32.

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title = "Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation",

abstract = "This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A \& B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program \#298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.",

author = "Llorente, \{Antolin M.\} and \{Van Gorp\}, \{Wilfred G.\} and Stern, \{Martin J.\} and Lance George and Paul Satz and Marcotte, \{Thomas D.\} and Calvillo, \{Gilbert M.\} and Hinkin, \{Charles H.\}",

year = "2001",

doi = "10.1017/S1355617701711034",

language = "English (US)",

volume = "7",

pages = "27--32",

journal = "Journal of the International Neuropsychological Society",

issn = "1355-6177",

publisher = "Cambridge University Press",

number = "1",

}

Llorente, AM, Van Gorp, WG, Stern, MJ, George, L, Satz, P, Marcotte, TD, Calvillo, GM & Hinkin, CH 2001, 'Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation', Journal of the International Neuropsychological Society, vol. 7, no. 1, pp. 27-32. https://doi.org/10.1017/S1355617701711034

Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation. / Llorente, Antolin M.; Van Gorp, Wilfred G.; Stern, Martin J. et al.
In: Journal of the International Neuropsychological Society, Vol. 7, No. 1, 2001, p. 27-32.

Research output: Contribution to journal › Article › peer-review

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T1 - Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients

T2 - Results of a randomized, double-blind, placebo-controlled investigation

AU - Llorente, Antolin M.

AU - Van Gorp, Wilfred G.

AU - Stern, Martin J.

AU - George, Lance

AU - Satz, Paul

AU - Marcotte, Thomas D.

AU - Calvillo, Gilbert M.

AU - Hinkin, Charles H.

PY - 2001

Y1 - 2001

N2 - This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.

AB - This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.

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Llorente AM, Van Gorp WG, Stern MJ, George L, Satz P, Marcotte TD et al. Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation. Journal of the International Neuropsychological Society. 2001;7(1):27-32. doi: 10.1017/S1355617701711034

Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Abstract

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