Long-term follow-up of continuous flow left ventricular assist devices: Complications and predisposing risk factors

Tolulope A. Adesiyun, Rhondalyn C. McLean, Ryan J. Tedford, Glenn J.R. Whitman, Chris M. Sciortino, John V. Conte, Ashish S. Shah, Stuart D. Russell

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose: To assess LVAD complications and their overall effect on mortality and determine factors associated with development of early and longe-trm complications. Methods: A retrospective cohort study of patients who underwent continuous flow LVAD placement between January 1, 2000 and November 30, 2013 was performed. The incidence of complications (sepsis or bacteremia, driveline infections, gastrointestinal bleeding, pump thrombosis, cerebrovascular accidents and anemia requiring transfusion) was collected and logistic regression and Cox proportional hazards analyses were performed. Results: 108 patients met our inclusion criteria. Median length of follow-up was 2.2 years. In univariable logistic regression analysis, higher blood urea nitrogen (BUN), creatinine clearance <60, no prior inotrope use, higher INTERMACS class and lower platelet count were associated with early complications. On multivariable analysis, factors associated with early complications included higher BUN (odds ratio (OR) 1.03, 95% confidence interval (CI) 1.001-1.06 per mg/dL BUN), no prior inotrope use (OR 4.92, 95% CI1.64-14.7) and lower platelet count (OR 4.29, 95% CI 1.45-12.7 <200 10(3) cu mm); 24% of patients developed early complications and 18.5% developed an early and late complication. Early complications were significantly associated with death (p = 0.017). The presence of 2 or more complications was associated with a 2.7-fold increase in the odds of death (p = 0.016) and odds of death increased by 20% with each susbequent complication (p = 0.004). Conclusions: LVADs are associated with significant long-term complications including stroke and sepsis and minimizing time on VLADs may decrease the risk of ocmplications and subsequent morbidity and moratlity.

Original languageEnglish (US)
Pages (from-to)622-628
Number of pages7
JournalInternational Journal of Artificial Organs
Issue number11
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials


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