Abstract
A sleep laboratory hypnotic drug evaluation study was conducted in which 2 mg flunitrazepam, a benzodiazepine with a half life of intermediate duration, was administered nightly to 6 insomniac subjects for 4 consecutive weeks. The drug was effective with short-term use. However, tolerance developed for sleep maintenance during the intermediate- and long-term drug administration periods. Following drug withdrawal, a significant worsening of sleep above baseline levels occurred. These data are consistent with our previous findings of rebound insomnia following withdrawal of short- and intermediate-acting benzodiazepines.
Original language | English (US) |
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Pages (from-to) | 173-181 |
Number of pages | 9 |
Journal | Pharmacology |
Volume | 19 |
Issue number | 4 |
DOIs | |
State | Published - 1979 |
All Science Journal Classification (ASJC) codes
- Pharmacology