Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues

Z. C. Lai; E. Rushton; M. Bate; G. M. Rubin

Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues

Z. C. Lai, E. Rushton, M. Bate, G. M. Rubin

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Abstract

The Drosophila zfh-1 gene encodes an unusual protein with nine Cys₂His₂ type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.

Original language	English (US)
Pages (from-to)	4122-4126
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	90
Issue number	9
State	Published - May 1 1993

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AU - Rushton, E.

AU - Bate, M.

AU - Rubin, G. M.

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N2 - The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.

AB - The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.

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JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues

Abstract

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