Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

T. C. Montie; D. Doyle Huntzinger; R. C. Craven; I. A. Holder

doi:10.1128/iai.38.3.1296-1298.1982

Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

T. C. Montie
, D. Doyle Huntzinger
, R. C. Craven
, I. A. Holder

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla^- mutant was isolated. An M-2 Fla^- spontaneous motile revertant was isolated from M-2 Fla^-. The three strains were biochemically and morphologically identical. Assay of Fla⁺ in the burned-mouse model showed a severe loss of virulence. The Fla⁺ revertant was fully virulent. The immportance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.

Original language	English (US)
Pages (from-to)	1296-1298
Number of pages	3
Journal	Infection and Immunity
Volume	38
Issue number	3
DOIs	https://doi.org/10.1128/iai.38.3.1296-1298.1982
State	Published - 1982

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/iai.38.3.1296-1298.1982

Cite this

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title = "Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model",

abstract = "To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla- mutant was isolated. An M-2 Fla- spontaneous motile revertant was isolated from M-2 Fla-. The three strains were biochemically and morphologically identical. Assay of Fla+ in the burned-mouse model showed a severe loss of virulence. The Fla+ revertant was fully virulent. The immportance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.",

author = "Montie, \{T. C.\} and \{Doyle Huntzinger\}, D. and Craven, \{R. C.\} and Holder, \{I. A.\}",

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T1 - Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

AU - Montie, T. C.

AU - Doyle Huntzinger, D.

AU - Craven, R. C.

AU - Holder, I. A.

PY - 1982

Y1 - 1982

N2 - To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla- mutant was isolated. An M-2 Fla- spontaneous motile revertant was isolated from M-2 Fla-. The three strains were biochemically and morphologically identical. Assay of Fla+ in the burned-mouse model showed a severe loss of virulence. The Fla+ revertant was fully virulent. The immportance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.

AB - To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla- mutant was isolated. An M-2 Fla- spontaneous motile revertant was isolated from M-2 Fla-. The three strains were biochemically and morphologically identical. Assay of Fla+ in the burned-mouse model showed a severe loss of virulence. The Fla+ revertant was fully virulent. The immportance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.

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JO - Infection and Immunity

JF - Infection and Immunity

IS - 3

ER -

Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

Abstract

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