Low-cost photoacoustic computed tomography system using light-emitting-diodes

Sumit Agrawal; Xinyi Yang; Hussain Albahrani; Christopher Fadden; Ajay Dangi; Mithun Kuniyil Ajith Singh; Sri Rajasekhar Kothapalli

doi:10.1117/12.2546993

Low-cost photoacoustic computed tomography system using light-emitting-diodes

Sumit Agrawal
, Xinyi Yang
, Hussain Albahrani
, Christopher Fadden
, Ajay Dangi
, Mithun Kuniyil Ajith Singh
, Sri Rajasekhar Kothapalli

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.

Original language	English (US)
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2020
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781510632431
DOIs	https://doi.org/10.1117/12.2546993
State	Published - 2020
Event	Photons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States Duration: Feb 2 2020 → Feb 5 2020

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11240
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2020
Country/Territory	United States
City	San Francisco
Period	2/2/20 → 2/5/20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2546993

Cite this

Agrawal, S., Yang, X., Albahrani, H., Fadden, C., Dangi, A., Singh, M. K. A., & Kothapalli, S. R. (2020). Low-cost photoacoustic computed tomography system using light-emitting-diodes. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2020 Article 1124058 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11240). SPIE. https://doi.org/10.1117/12.2546993

@inproceedings{80fb19d039fa43d2809908ed735cf17b,

title = "Low-cost photoacoustic computed tomography system using light-emitting-diodes",

abstract = "Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.",

author = "Sumit Agrawal and Xinyi Yang and Hussain Albahrani and Christopher Fadden and Ajay Dangi and Singh, \{Mithun Kuniyil Ajith\} and Kothapalli, \{Sri Rajasekhar\}",

note = "Funding Information: This project was partially funded by the NIH-NIBIB R00EB017729-04 (SRK) and Penn State Cancer Institute (SRK). We also acknowledge the support of NVIDIA Corporation with the donation of the Titan X Pascal GPU used for the reconstruction of LED-PAT images. We further thank CYBERDYNE Inc. for their technical support. Publisher Copyright: {\textcopyright} 2020 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2020 ; Conference date: 02-02-2020 Through 05-02-2020",

year = "2020",

doi = "10.1117/12.2546993",

language = "English (US)",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, \{Alexander A.\} and Wang, \{Lihong V.\}",

booktitle = "Photons Plus Ultrasound",

address = "United States",

}

Agrawal, S, Yang, X, Albahrani, H, Fadden, C, Dangi, A, Singh, MKA & Kothapalli, SR 2020, Low-cost photoacoustic computed tomography system using light-emitting-diodes. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124058, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546993

Low-cost photoacoustic computed tomography system using light-emitting-diodes. / Agrawal, Sumit; Yang, Xinyi; Albahrani, Hussain et al.
Photons Plus Ultrasound: Imaging and Sensing 2020. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2020. 1124058 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11240).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Low-cost photoacoustic computed tomography system using light-emitting-diodes

AU - Agrawal, Sumit

AU - Yang, Xinyi

AU - Albahrani, Hussain

AU - Fadden, Christopher

AU - Dangi, Ajay

AU - Singh, Mithun Kuniyil Ajith

AU - Kothapalli, Sri Rajasekhar

N1 - Funding Information: This project was partially funded by the NIH-NIBIB R00EB017729-04 (SRK) and Penn State Cancer Institute (SRK). We also acknowledge the support of NVIDIA Corporation with the donation of the Titan X Pascal GPU used for the reconstruction of LED-PAT images. We further thank CYBERDYNE Inc. for their technical support. Publisher Copyright: © 2020 SPIE.

PY - 2020

Y1 - 2020

N2 - Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.

AB - Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.

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UR - https://www.scopus.com/pages/publications/85082689238#tab=citedBy

U2 - 10.1117/12.2546993

DO - 10.1117/12.2546993

M3 - Conference contribution

AN - SCOPUS:85082689238

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2020

Y2 - 2 February 2020 through 5 February 2020

ER -

Low-cost photoacoustic computed tomography system using light-emitting-diodes

Abstract

Publication series

Conference

UN SDGs

All Science Journal Classification (ASJC) codes

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