Low-intensity pulsed ultrasound does not enhance distraction callus in a rabbit model

Kenneth F. Taylor, Bahman Rafiee, John E. Tis, Nozumu Inoue

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Low-intensity pulsed ultrasound has been reported to have a positive effect when applied during the consolidation phase of distraction osteogenesis and bone transportation, but the optimal application time has not been determined. We used a rabbit model to determine whether low-intensity pulsed ultrasound applied during the distraction and early consolidation phases of tibial lengthening would have a positive effect on regenerated bone formation. Radiographic analysis showed no differences in regenerated callus area or in percent of callus mineralization between treated and control tibias immediately after distraction or at 1, 2, or 3 weeks after distraction. Similarly, we observed no differences in structural stiffness or maximal torque to failure at 1.5 or 3 weeks after distraction. We detected no differences in bone mineral appositional rates or percent tissue composition measured histologically between groups. Our data do not support the application of low-intensity pulsed ultrasound to regenerated bone during distraction osteogenesis.

Original languageEnglish (US)
Pages (from-to)237-245
Number of pages9
JournalClinical orthopaedics and related research
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine


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