LSPR sensing of molecular biothiols based on noncoupled gold nanorods

Chong Li; Chuanliu Wu; Jinsheng Zheng; Jinping Lai; Chenlong Zhang; Yibing Zhao

doi:10.1021/la101285r

LSPR sensing of molecular biothiols based on noncoupled gold nanorods

Chong Li, Chuanliu Wu, Jinsheng Zheng, Jinping Lai, Chenlong Zhang, Yibing Zhao

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Au NRs protected with mPEG-SH molecules (mPEG-Au NRs) were demonstrated to be a promising platform for LSPR-based sensing of molecular biothiols in aqueous solution. Surface mPEG-SH molecules endow Au NRs with great stability and biocompatibility and no nonspecific adsorption of biomacromolecules. The LSPR band of mPEG-Au NRs displays a stability and linear response in the spectral shift with respect to a change in their surrounding refractive index with a sensitivity of 252 nm/RIU. The loose structure of mPEG-SH around the Au NRs offers free sites, thereby allowing molecular biothiols to bind onto the surfaces of Au NRs. The LSPR response and the sensitivity of Au NRs to biothiols such as GSH, Cys, Hcy, TGA, GSSG, and BSA were then studied.

Original language	English (US)
Pages (from-to)	9130-9135
Number of pages	6
Journal	Langmuir
Volume	26
Issue number	11
DOIs	https://doi.org/10.1021/la101285r
State	Published - Jun 1 2010

All Science Journal Classification (ASJC) codes

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la101285r

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title = "LSPR sensing of molecular biothiols based on noncoupled gold nanorods",

abstract = "Au NRs protected with mPEG-SH molecules (mPEG-Au NRs) were demonstrated to be a promising platform for LSPR-based sensing of molecular biothiols in aqueous solution. Surface mPEG-SH molecules endow Au NRs with great stability and biocompatibility and no nonspecific adsorption of biomacromolecules. The LSPR band of mPEG-Au NRs displays a stability and linear response in the spectral shift with respect to a change in their surrounding refractive index with a sensitivity of 252 nm/RIU. The loose structure of mPEG-SH around the Au NRs offers free sites, thereby allowing molecular biothiols to bind onto the surfaces of Au NRs. The LSPR response and the sensitivity of Au NRs to biothiols such as GSH, Cys, Hcy, TGA, GSSG, and BSA were then studied.",

author = "Chong Li and Chuanliu Wu and Jinsheng Zheng and Jinping Lai and Chenlong Zhang and Yibing Zhao",

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TY - JOUR

T1 - LSPR sensing of molecular biothiols based on noncoupled gold nanorods

AU - Li, Chong

AU - Wu, Chuanliu

AU - Zheng, Jinsheng

AU - Lai, Jinping

AU - Zhang, Chenlong

AU - Zhao, Yibing

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Au NRs protected with mPEG-SH molecules (mPEG-Au NRs) were demonstrated to be a promising platform for LSPR-based sensing of molecular biothiols in aqueous solution. Surface mPEG-SH molecules endow Au NRs with great stability and biocompatibility and no nonspecific adsorption of biomacromolecules. The LSPR band of mPEG-Au NRs displays a stability and linear response in the spectral shift with respect to a change in their surrounding refractive index with a sensitivity of 252 nm/RIU. The loose structure of mPEG-SH around the Au NRs offers free sites, thereby allowing molecular biothiols to bind onto the surfaces of Au NRs. The LSPR response and the sensitivity of Au NRs to biothiols such as GSH, Cys, Hcy, TGA, GSSG, and BSA were then studied.

AB - Au NRs protected with mPEG-SH molecules (mPEG-Au NRs) were demonstrated to be a promising platform for LSPR-based sensing of molecular biothiols in aqueous solution. Surface mPEG-SH molecules endow Au NRs with great stability and biocompatibility and no nonspecific adsorption of biomacromolecules. The LSPR band of mPEG-Au NRs displays a stability and linear response in the spectral shift with respect to a change in their surrounding refractive index with a sensitivity of 252 nm/RIU. The loose structure of mPEG-SH around the Au NRs offers free sites, thereby allowing molecular biothiols to bind onto the surfaces of Au NRs. The LSPR response and the sensitivity of Au NRs to biothiols such as GSH, Cys, Hcy, TGA, GSSG, and BSA were then studied.

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LSPR sensing of molecular biothiols based on noncoupled gold nanorods

Abstract

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