Lymphatic absorption of enterally fed structured triacylglycerol vs physical mix in a canine model

Gordon L. Jensen, Niall McGarvey, Robert Taraszewski, Sally K. Wixson, Douglas L. Seidner, Tongkun Pai, Yu Yan Yeh, Theresa W. Lee, Stephen J. Demichele

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50 Scopus citations


The lymphatic absorption of a structured triacylglycerol vs an equivalent physical mixture of the constituent medium-chain triacylglycerol and fish oils was studied. Each of four canines served as its own control in a crossover feeding design with the investigators unaware of diet contents. Lymphatic absorption of n-3 and medium-chain fatty acids peaked within 4-8 h of feeding either diet. The lymph contained more 10:0 fatty acids than 8:0 despite an overall ratio of 10:0 to 8:0 of 0.3 for the diets. The mass of medium-chain fatty acids absorbed in the lymph at measured time points was 2.6 ± 0.5-fold higher (x̄ ± SE of 12 determinations) for the structured triacylglycerol compared with the physical mix. Molecular species analyses revealed that the medium-chain fatty acids in lymph were present as mixed triacylglycerols. The unique molecular structure of these mixed triacylglycerols and the fatty acids at the 2-position may account for the improved absorption.

Original languageEnglish (US)
Pages (from-to)518-524
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - Oct 1994

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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