Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function

Emily Ling Lin Pai; Daniel Vogt; Alexandra Clemente-Perez; Gabriel L. McKinsey; Frances S. Cho; Jia Sheng Hu; Matt Wimer; Anirban Paul; Siavash Fazel Darbandi; Ramon Pla; Tomasz J. Nowakowski; Lisa V. Goodrich; Jeanne T. Paz; John L.R. Rubenstein

doi:10.1016/j.celrep.2019.01.031

Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function

Emily Ling Lin Pai, Daniel Vogt, Alexandra Clemente-Perez, Gabriel L. McKinsey, Frances S. Cho, Jia Sheng Hu, Matt Wimer, Anirban Paul, Siavash Fazel Darbandi, Ramon Pla, Tomasz J. Nowakowski, Lisa V. Goodrich, Jeanne T. Paz, John L.R. Rubenstein

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Abstract

Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV⁺) and somatostatin (SST⁺) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST⁺ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.

Original language	English (US)
Pages (from-to)	1157-1173.e5
Journal	Cell Reports
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2019.01.031
State	Published - Jan 29 2019

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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Pai, E. L. L., Vogt, D., Clemente-Perez, A., McKinsey, G. L., Cho, F. S., Hu, J. S., Wimer, M., Paul, A., Fazel Darbandi, S., Pla, R., Nowakowski, T. J., Goodrich, L. V., Paz, J. T., & Rubenstein, J. L. R. (2019). Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Reports, 26(5), 1157-1173.e5. https://doi.org/10.1016/j.celrep.2019.01.031

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title = "Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function",

abstract = "Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.",

author = "Pai, {Emily Ling Lin} and Daniel Vogt and Alexandra Clemente-Perez and McKinsey, {Gabriel L.} and Cho, {Frances S.} and Hu, {Jia Sheng} and Matt Wimer and Anirban Paul and {Fazel Darbandi}, Siavash and Ramon Pla and Nowakowski, {Tomasz J.} and Goodrich, {Lisa V.} and Paz, {Jeanne T.} and Rubenstein, {John L.R.}",

note = "Publisher Copyright: {\textcopyright} 2019 UCSF",

year = "2019",

month = jan,

day = "29",

doi = "10.1016/j.celrep.2019.01.031",

language = "English (US)",

volume = "26",

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journal = "Cell Reports",

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Pai, ELL, Vogt, D, Clemente-Perez, A, McKinsey, GL, Cho, FS, Hu, JS, Wimer, M, Paul, A, Fazel Darbandi, S, Pla, R, Nowakowski, TJ, Goodrich, LV, Paz, JT & Rubenstein, JLR 2019, 'Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function', Cell Reports, vol. 26, no. 5, pp. 1157-1173.e5. https://doi.org/10.1016/j.celrep.2019.01.031

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T1 - Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function

AU - Pai, Emily Ling Lin

AU - Vogt, Daniel

AU - Clemente-Perez, Alexandra

AU - McKinsey, Gabriel L.

AU - Cho, Frances S.

AU - Hu, Jia Sheng

AU - Wimer, Matt

AU - Paul, Anirban

AU - Fazel Darbandi, Siavash

AU - Pla, Ramon

AU - Nowakowski, Tomasz J.

AU - Goodrich, Lisa V.

AU - Paz, Jeanne T.

AU - Rubenstein, John L.R.

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.

AB - Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.

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Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function

Abstract

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