TY - JOUR
T1 - Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function
AU - Pai, Emily Ling Lin
AU - Vogt, Daniel
AU - Clemente-Perez, Alexandra
AU - McKinsey, Gabriel L.
AU - Cho, Frances S.
AU - Hu, Jia Sheng
AU - Wimer, Matt
AU - Paul, Anirban
AU - Fazel Darbandi, Siavash
AU - Pla, Ramon
AU - Nowakowski, Tomasz J.
AU - Goodrich, Lisa V.
AU - Paz, Jeanne T.
AU - Rubenstein, John L.R.
N1 - Publisher Copyright:
© 2019 UCSF
PY - 2019/1/29
Y1 - 2019/1/29
N2 - Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.
AB - Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.
UR - https://www.scopus.com/pages/publications/85060326599
UR - https://www.scopus.com/pages/publications/85060326599#tab=citedBy
U2 - 10.1016/j.celrep.2019.01.031
DO - 10.1016/j.celrep.2019.01.031
M3 - Article
C2 - 30699346
AN - SCOPUS:85060326599
SN - 2211-1247
VL - 26
SP - 1157-1173.e5
JO - Cell Reports
JF - Cell Reports
IS - 5
ER -