TY - JOUR
T1 - Magnesium
T2 - A new therapy for idiopathic sudden sensorineural hearing loss
AU - Gordin, Arie
AU - Goldenberg, David
AU - Golz, Avishay
AU - Netzer, Aviram
AU - Joachims, Henry Zvi
PY - 2002
Y1 - 2002
N2 - Objective: To determine whether treatment with Mg2+ improves the outcome of idiopathic sudden hearing loss and to investigate which variables influence its prognosis. Study Design: Prospective randomized study. Setting: Department of Otolaryngology-Head and Neck Surgery, Rambam Medical Center, Haifa, Israel. Patients: The study group included 133 patients. Sixty patients were treated with carbogen inhalation, and 73 were treated with a combination of carbogen inhalation and intravenous MgSO4. Results: The mean improvement rate was 66.4% in the Mg2+ group and 49.9% in the carbogen group (p < 0.01). Recovery was achieved in 35 patients (48%) in the Mg2+ group and only in 19 patients (31.6%) in the carbogen group (p < 0.01). Significant improvement was seen in 20 patients (27.4%) in the Mg2+ group and in 14 patients (23.3%) in the carbogen group. Partial improvement was seen in eight patients (10.9%) in the Mg2+ group and in 12 patients (20%) in the carbogen group. No improvement was achieved in 10 patients (13.6%) in the Mg2+ group and in 15 patients (25%) in the carbogen group. Patients with vestibular symptoms had a poorer hearing outcome compared to those without vertigo (p < 0.04). Patients who commenced the treatment 8 days or more after onset had poorer recovery as compared with those who started treatment earlier (p < 0.03), regardless of the treatment regimen. Age, sex, and tinnitus had no significant impact on hearing recovery. Conclusion: We found that Mg2+ improved hearing recovery in cases of idiopathic sudden hearing loss. Vertigo and treatment delay beyond 8 days were poor prognostic factors for recovery.
AB - Objective: To determine whether treatment with Mg2+ improves the outcome of idiopathic sudden hearing loss and to investigate which variables influence its prognosis. Study Design: Prospective randomized study. Setting: Department of Otolaryngology-Head and Neck Surgery, Rambam Medical Center, Haifa, Israel. Patients: The study group included 133 patients. Sixty patients were treated with carbogen inhalation, and 73 were treated with a combination of carbogen inhalation and intravenous MgSO4. Results: The mean improvement rate was 66.4% in the Mg2+ group and 49.9% in the carbogen group (p < 0.01). Recovery was achieved in 35 patients (48%) in the Mg2+ group and only in 19 patients (31.6%) in the carbogen group (p < 0.01). Significant improvement was seen in 20 patients (27.4%) in the Mg2+ group and in 14 patients (23.3%) in the carbogen group. Partial improvement was seen in eight patients (10.9%) in the Mg2+ group and in 12 patients (20%) in the carbogen group. No improvement was achieved in 10 patients (13.6%) in the Mg2+ group and in 15 patients (25%) in the carbogen group. Patients with vestibular symptoms had a poorer hearing outcome compared to those without vertigo (p < 0.04). Patients who commenced the treatment 8 days or more after onset had poorer recovery as compared with those who started treatment earlier (p < 0.03), regardless of the treatment regimen. Age, sex, and tinnitus had no significant impact on hearing recovery. Conclusion: We found that Mg2+ improved hearing recovery in cases of idiopathic sudden hearing loss. Vertigo and treatment delay beyond 8 days were poor prognostic factors for recovery.
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U2 - 10.1097/00129492-200207000-00009
DO - 10.1097/00129492-200207000-00009
M3 - Article
C2 - 12170143
AN - SCOPUS:0036066919
SN - 1531-7129
VL - 23
SP - 447
EP - 451
JO - Otology and Neurotology
JF - Otology and Neurotology
IS - 4
ER -