Magnesium abnormalities of skeletal muscle in dermatomyositis and juvenile dermatomyositis

Kenneth J. Niermann, Nancy J. Olsen, Jane H. Park

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective. To characterize abnormalities in magnesium levels in the muscles of patients with dermatomyositis (DM) and juvenile dermatomyositis (JDM) and to evaluate the beneficial effects of prednisone and immunosuppressive therapy in elevating free magnesium (Mg 2+) and ATP-bound magnesium (Mg-ATP). Methods. The study groups consisted of 12 adult patients with DM and 10 juvenile patients with JDM. The 2 control groups were 11 normal adults and 6 healthy children. Levels of total ATP in the quadriceps muscles of the subjects were determined during rest, exercise, and recovery, using noninvasive P-31 magnetic resonance spectroscopy (MRS). Concentrations of the biologically active free Mg 2+ and the enzymatically active Mg-ATP complex were determined from the spectroscopy data by calculation of the chemical shifts of the β-phosphate peak of ATP. Results. Mg-ATP levels in DM and JDM myopathic muscles were at least 37% lower than those in normal muscles during rest, exercise, and recovery from exercise (P < 0.0005). Free Mg 2+ levels were normal in DM and JDM myopathic muscles at rest, but were significantly lower than control values during exercise and recovery (P < 0.029 and P < 0.005 for DM and JDM, respectively). Prednisone and immunosuppressive therapy partially reversed the magnesium abnormalities, as evidenced by elevation of the levels of Mg-ATP and free Mg 2+. Conclusion. Low levels of Mg-ATP and free Mg 2+ are concordant with weakness and fatigue observed in DM and JDM patients. Immunosuppressive therapy alleviates, in part, the magnesium deficits in the diseased muscles. Therefore, Mg-ATP and free Mg 2+ may play a significant role in the pathophysiology of these diseases.

Original languageEnglish (US)
Pages (from-to)475-488
Number of pages14
JournalArthritis and rheumatism
Issue number2
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


Dive into the research topics of 'Magnesium abnormalities of skeletal muscle in dermatomyositis and juvenile dermatomyositis'. Together they form a unique fingerprint.

Cite this