Magnetic resonance elastography in the liver at 3 Tesla using a second harmonic approach

Daniel A. Herzka, M. S. Kotys, R. Sinkus, R. I. Pettigrew, A. M. Gharib

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Magnetic resonance elastography (MRE) using mechanical stimulation has demonstrated diagnostic value and clinical promise in breast, liver, and kidney at 1.5 Tesla (T). However, MRE at 1.5T suffers from long imaging times and would benefit from greater signal-to-noise for more robust postprocessing. We present an MRE sequence modified for liver imaging at 3.0T. To avoid artifacts in the phase images, the sequence maintains a short TE by using a second harmonic approach, including stronger motion encoding gradients, shorter radio frequency pulses and an echo-planar readout. Scan time was decreased by a factor of ∼2 relative to 1.5T by using an EPI readout and a higher density sampling of the phase waveform was used to calculate shear stiffness and viscosity. Localized (small region of interest) and global (whole-liver region of interest) measurements in normal healthy subjects compared very favorably with previously published results at 1.5T. There was no significant difference between global and localized measures.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - Aug 2009

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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