Malignant transformation and subsequent leptomeningeal carcinomatosis of a gastric polyp in a dog

Dillon S. Didehvar; Matthew R. Lanza; Matthew J. Atherton; Jennifer A. Lenz

doi:10.1111/jvim.17072

Malignant transformation and subsequent leptomeningeal carcinomatosis of a gastric polyp in a dog

Dillon S. Didehvar, Matthew R. Lanza, Matthew J. Atherton, Jennifer A. Lenz

Department of Comparative Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Progressive carcinogenesis of a gastric polyp with transformation to gastric adenocarcinoma and subsequent development of leptomeningeal carcinomatosis is described in an adult male Scottish terrier. Presenting clinical signs consisted of vomiting with intermittent hematemesis. Surgical biopsies over the course of 14 months documented the progression from gastric polyp to minimally invasive gastric carcinoma to invasive gastric adenocarcinoma, a pathogenesis not previously documented in veterinary oncology. The patient ultimately developed neurologic pathology and was euthanized, and necropsy evaluation identified widespread carcinomatosis with accompanying leptomeningeal metastasis. As in humans, gastric polyps in dogs rarely have malignant potential.

Original language	English (US)
Pages (from-to)	1744-1750
Number of pages	7
Journal	Journal of Veterinary Internal Medicine
Volume	38
Issue number	3
DOIs	https://doi.org/10.1111/jvim.17072
State	Published - May 1 2024

All Science Journal Classification (ASJC) codes

General Veterinary

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10.1111/jvim.17072

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title = "Malignant transformation and subsequent leptomeningeal carcinomatosis of a gastric polyp in a dog",

abstract = "Progressive carcinogenesis of a gastric polyp with transformation to gastric adenocarcinoma and subsequent development of leptomeningeal carcinomatosis is described in an adult male Scottish terrier. Presenting clinical signs consisted of vomiting with intermittent hematemesis. Surgical biopsies over the course of 14 months documented the progression from gastric polyp to minimally invasive gastric carcinoma to invasive gastric adenocarcinoma, a pathogenesis not previously documented in veterinary oncology. The patient ultimately developed neurologic pathology and was euthanized, and necropsy evaluation identified widespread carcinomatosis with accompanying leptomeningeal metastasis. As in humans, gastric polyps in dogs rarely have malignant potential.",

author = "Didehvar, {Dillon S.} and Lanza, {Matthew R.} and Atherton, {Matthew J.} and Lenz, {Jennifer A.}",

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N2 - Progressive carcinogenesis of a gastric polyp with transformation to gastric adenocarcinoma and subsequent development of leptomeningeal carcinomatosis is described in an adult male Scottish terrier. Presenting clinical signs consisted of vomiting with intermittent hematemesis. Surgical biopsies over the course of 14 months documented the progression from gastric polyp to minimally invasive gastric carcinoma to invasive gastric adenocarcinoma, a pathogenesis not previously documented in veterinary oncology. The patient ultimately developed neurologic pathology and was euthanized, and necropsy evaluation identified widespread carcinomatosis with accompanying leptomeningeal metastasis. As in humans, gastric polyps in dogs rarely have malignant potential.

AB - Progressive carcinogenesis of a gastric polyp with transformation to gastric adenocarcinoma and subsequent development of leptomeningeal carcinomatosis is described in an adult male Scottish terrier. Presenting clinical signs consisted of vomiting with intermittent hematemesis. Surgical biopsies over the course of 14 months documented the progression from gastric polyp to minimally invasive gastric carcinoma to invasive gastric adenocarcinoma, a pathogenesis not previously documented in veterinary oncology. The patient ultimately developed neurologic pathology and was euthanized, and necropsy evaluation identified widespread carcinomatosis with accompanying leptomeningeal metastasis. As in humans, gastric polyps in dogs rarely have malignant potential.

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Malignant transformation and subsequent leptomeningeal carcinomatosis of a gastric polyp in a dog

Abstract

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