Mammalian gut immunity

Benoit Chassaing, Manish Kumar, Mark T. Baker, Vishal Singh, Matam Vijay-Kumar

Research output: Contribution to journalReview articlepeer-review

114 Scopus citations

Abstract

The mammalian intestinal tract is the largest immune organ in the body and comprises cells from non-hemopoietic (epithelia, Paneth cells, goblet cells) and hemopoietic (macrophages, dendritic cells, T-cells) origin, and is also a dwelling for trillions of microbes collectively known as the microbiota. The homeostasis of this large microbial biomass is prerequisite to maintain host health by maximizing beneficial symbiotic relationships and minimizing the risks of living in such close proximity. Both microbiota and host immune system communicate with each other to mutually maintain homeostasis in what could be called a "love-hate relationship." Further, the host innate and adaptive immune arms of the immune system cooperate and compensate each other to maintain the equilibrium of a highly complex gut ecosystem in a stable and stringent fashion. Any imbalance due to innate or adaptive immune deficiency or aberrant immune response may lead to dysbiosis and low-grade to robust gut inflammation, finally resulting in metabolic diseases.

Original languageEnglish (US)
Pages (from-to)246-258
Number of pages13
JournalBiomedical Journal
Volume37
Issue number5
DOIs
StatePublished - Sep 1 2014

All Science Journal Classification (ASJC) codes

  • General Medicine

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