Management of patients with low-grade liposarcoma, or atypical lipoma

G. Douglas Letson, Henry Wagner, Carlos A. Muro-Cacho

Research output: Contribution to journalReview articlepeer-review


Liposarcomas are a heterogeneous group of tumors with variable histopathology and clinical behavior. Accurate diagnosis, subtyping, and grading are essential to select appropriate treatment. We I-differentiated tumors are slow-growing and may reach large sizes without symptoms. They are considered local diseases with low metastatic potential but with a tender cy to recur and transform into aggressive sarcomas, To prevent excessive treatment of these indolent tumors, terms such "atypical lipomatous tumor" or "atypical lipoma" have been proposed, and although a consensus has not yet been reached, conservative surgical resection with attention to margins is favored. When negative margins are not obtained, adiotherapy may decrease local recurrence. Myxoid variants often metastasize and should be treated aggressively with surgery and judicious use of preoperative or postoperative radiotherapy. Resection of pulmonary metastases prolongs survival in selected patients. Chemotherapy benefits 25% of patients with metastatic or unresectable disease. Its optimal integration with local treatments in adjuvant or neoadjuvant settings is the focus of ongoing clinical trials.

Original languageEnglish (US)
Pages (from-to)454-460
Number of pages7
JournalCurrent Opinion in Orthopaedics
Issue number6
StatePublished - Dec 2002

All Science Journal Classification (ASJC) codes

  • Surgery


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