Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Jing Xie; Seneca L. Bessling; Timothy K. Cooper; Harry C. Dietz; Andrew S. McCallion; Shannon Fisher

doi:10.1534/genetics.107.072983

Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Jing Xie, Seneca L. Bessling, Timothy K. Cooper, Harry C. Dietz, Andrew S. McCallion, Shannon Fisher

Department of Comparative Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

Original language	English (US)
Pages (from-to)	1339-1342
Number of pages	4
Journal	Genetics
Volume	176
Issue number	2
DOIs	https://doi.org/10.1534/genetics.107.072983
State	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Genetics

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10.1534/genetics.107.072983

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title = "Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases",

abstract = "RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.",

author = "Jing Xie and Bessling, {Seneca L.} and Cooper, {Timothy K.} and Dietz, {Harry C.} and McCallion, {Andrew S.} and Shannon Fisher",

year = "2007",

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doi = "10.1534/genetics.107.072983",

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journal = "Genetics",

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publisher = "Oxford University Press",

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T1 - Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

AU - Xie, Jing

AU - Bessling, Seneca L.

AU - Cooper, Timothy K.

AU - Dietz, Harry C.

AU - McCallion, Andrew S.

AU - Fisher, Shannon

PY - 2007/6

Y1 - 2007/6

N2 - RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

AB - RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

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JF - Genetics

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Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Abstract

All Science Journal Classification (ASJC) codes

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