Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Jing Xie; Seneca L. Bessling; Timothy K. Cooper; Harry C. Dietz; Andrew S. McCallion; Shannon Fisher

doi:10.1534/genetics.107.072983

Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Jing Xie
, Seneca L. Bessling
, Timothy K. Cooper
, Harry C. Dietz
, Andrew S. McCallion
, Shannon Fisher

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

Original language	English (US)
Pages (from-to)	1339-1342
Number of pages	4
Journal	Genetics
Volume	176
Issue number	2
DOIs	https://doi.org/10.1534/genetics.107.072983
State	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Genetics

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10.1534/genetics.107.072983

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title = "Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases",

abstract = "RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.",

author = "Jing Xie and Bessling, \{Seneca L.\} and Cooper, \{Timothy K.\} and Dietz, \{Harry C.\} and McCallion, \{Andrew S.\} and Shannon Fisher",

year = "2007",

month = jun,

doi = "10.1534/genetics.107.072983",

language = "English (US)",

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journal = "Genetics",

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publisher = "Oxford University Press",

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T1 - Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

AU - Xie, Jing

AU - Bessling, Seneca L.

AU - Cooper, Timothy K.

AU - Dietz, Harry C.

AU - McCallion, Andrew S.

AU - Fisher, Shannon

PY - 2007/6

Y1 - 2007/6

N2 - RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

AB - RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

UR - https://www.scopus.com/pages/publications/34250714533

UR - https://www.scopus.com/pages/publications/34250714533#tab=citedBy

U2 - 10.1534/genetics.107.072983

DO - 10.1534/genetics.107.072983

M3 - Article

C2 - 17483412

AN - SCOPUS:34250714533

SN - 0016-6731

VL - 176

SP - 1339

EP - 1342

JO - Genetics

JF - Genetics

IS - 2

ER -

Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Abstract

All Science Journal Classification (ASJC) codes

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