@article{ece55fbc33374812ac9cd3b8849faf01,
title = "Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice",
abstract = "The central nucleus of the amygdala plays a significant role in alcohol use and other affective disorders; however, the genetically-defined neuronal subtypes and projections that govern these behaviors are not well known. Here we show that neurotensin neurons in the central nucleus of the amygdala of male mice are activated by in vivo ethanol consumption and that genetic ablation of these neurons decreases ethanol consumption and preference in non-ethanol-dependent animals. This ablation did not impact preference for sucrose, saccharin, or quinine. We found that the most robust projection of the central amygdala neurotensin neurons was to the parabrachial nucleus, a brain region known to be important in feeding behaviors, conditioned taste aversion, and alarm. Optogenetic stimulation of projections from these neurons to the parabrachial nucleus is reinforcing, and increases ethanol drinking as well as consumption of sucrose and saccharin solutions. These data suggest that this central amygdala to parabrachial nucleus projection influences the expression of reward-related phenotypes and is a novel circuit promoting consumption of ethanol and palatable fluids.",
author = "Torruella-Su{\'a}rez, {Mar{\'i}a Luisa} and Vandenberg, {Jessica R.} and Cogan, {Elizabeth S.} and Tipton, {Gregory J.} and Adonay Teklezghi and Kedar Dange and Patel, {Gunjan K.} and McHenry, {Jenna A.} and {Andrew Hardaway}, J. and Kantak, {Pranish A.} and Crowley, {Nicole A.} and DiBerto, {Jeffrey F.} and Faccidomo, {Sara P.} and Hodge, {Clyde W.} and Stuber, {Garret D.} and McElligott, {Zo{\'e} A.}",
note = "Funding Information: This work was supported by: K01AA023555 (Z.A.M.), 550KR71419 (Z.A.M.), P60 AA011605 (C.W.H., G.D.S), R37AA014983 (C.W.H.), F31AA026183 (M.L.T.-S.), T32 NS007431 (M.L.T.-S), U01 AA020911 (Z.A.M.), U24 AA025475(Z.A.M.),K01DK115902(J.A.H.),DK056350NutritionObesityResearchCenterPilotandFeasibilityAward (Z.A.M.), and the Alcohol Beverage Medical Research Foundation (Z.A.M.) We thank Drs. Thomas Kash, Karl T. Schmidt, and Elyse Dankoski, as well as Madigan Lavery for comments on previous versions of the paper. The authors declare no competing financial interests. Correspondence should be addressed to Zo{\'e} A. McElligott at zoemce@email.unc.edu. https://doi.org/10.1523/JNEUROSCI.1466-19.2019 Copyright {\textcopyright} 2020 the authors Funding Information: This work was supported by: K01AA023555 (Z.A.M.), 550KR71419 (Z.A.M.), P60 AA011605 (C.W.H., G.D.S), R37AA014983 (C.W.H.), F31AA026183 (M.L.T.-S.), T32 NS007431 (M.L.T.-S), U01 AA020911 (Z.A.M.), U24 AA025475 (Z.A.M.), K01DK115902 (J.A.H.), DK056350 Nutrition Obesity Research Center Pilot and Feasibility Award (Z.A.M.), and the Alcohol Beverage Medical Research Foundation (Z.A.M.) We thank Drs. Thomas Kash, Karl T. Schmidt, and Elyse Dankoski, as well as Madigan Lavery for comments on previous versions of the paper. Publisher Copyright: Copyright {\textcopyright} 2020 the authors.",
year = "2020",
month = jan,
day = "15",
doi = "10.1523/JNEUROSCI.1466-19.2019",
language = "English (US)",
volume = "40",
pages = "632--647",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "3",
}