TY - JOUR
T1 - Mapping of class alpha glutathione S-transferase 2 (Gst-2) genes to the vicinity of the d locus on mouse chromosome 9
AU - Kasahara, Masanori
AU - Matsumura, Eriko
AU - Webb, Graham
AU - Board, Philip G.
AU - Figueroa, Felipe
AU - Klein, Jan
N1 - Funding Information:
The authors thank Ms. Margarethe Wiirstle for the isolation of DNAs from RI strains of mice, and Donna E. Sarapata for her technical and secretarial assistance. They also thank Dr. Joe Nadeau, The Jackson Laboratory, for reading the manuscript. This work was supported by National Institutes of Health Grants HD 25493 to M.K. and AI 23667 to J.K.
PY - 1990/9
Y1 - 1990/9
N2 - Recombinant inbred strains of mice were used to localize the genes coding for the class alpha glutathione S-transferase 2 (Gst-2). The genes showed three distinct strain distribution patterns, indicating that they occur in at least three clusters separable by recombination. All three clusters are located in the vicinity of the d locus on mouse chromosome 9, but two of them are closer to d than the third. Linked to Gst-2 on mouse chromosome 9 are two enzyme-encoding loci, Pgm-3 and Mod-1. The human counterparts of Gst-2, Pgm-3, and Mod-1 map to 6p12, 6q12, and 6q12, respectively. Thus, the pericentric region of human chromosome 6 has its homolog in the segment spanning Gst-2, Pgm-3, and Mod-1 on mouse chromosome 9. The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarrhini.
AB - Recombinant inbred strains of mice were used to localize the genes coding for the class alpha glutathione S-transferase 2 (Gst-2). The genes showed three distinct strain distribution patterns, indicating that they occur in at least three clusters separable by recombination. All three clusters are located in the vicinity of the d locus on mouse chromosome 9, but two of them are closer to d than the third. Linked to Gst-2 on mouse chromosome 9 are two enzyme-encoding loci, Pgm-3 and Mod-1. The human counterparts of Gst-2, Pgm-3, and Mod-1 map to 6p12, 6q12, and 6q12, respectively. Thus, the pericentric region of human chromosome 6 has its homolog in the segment spanning Gst-2, Pgm-3, and Mod-1 on mouse chromosome 9. The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarrhini.
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U2 - 10.1016/0888-7543(90)90229-N
DO - 10.1016/0888-7543(90)90229-N
M3 - Article
C2 - 1981995
AN - SCOPUS:0025164693
SN - 0888-7543
VL - 8
SP - 90
EP - 96
JO - Genomics
JF - Genomics
IS - 1
ER -