@inproceedings{b82910297c7043a284668838c84a6c8b,
title = "Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort",
abstract = "We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.",
author = "Carmichael, {Owen T.} and Thompson, {Paul M.} and Dutton, {Rebecca A.} and Allen Lu and Lee, {Sharon E.} and Lee, {Jessica Y.} and Kuller, {Lewis H.} and Lopez, {Oscar L.} and Aizenstein, {Howard J.} and Meltzer, {Carolyn Cidis} and Yanxi Liu and Toga, {Arthur W.} and Becker, {James T.}",
year = "2006",
language = "English (US)",
isbn = "0780395778",
series = "2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings",
pages = "315--318",
booktitle = "2006 3rd IEEE International Symposium on Biomedical Imaging",
note = "2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro ; Conference date: 06-04-2006 Through 09-04-2006",
}