TY - JOUR
T1 - Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects
AU - Bradley, David
AU - Magkos, Faidon
AU - Eagon, J. Christopher
AU - Varela, J. Esteban
AU - Gastaldelli, Amalia
AU - Okunade, Adewole L.
AU - Patterson, Bruce W.
AU - Klein, Samuel
PY - 2014/9
Y1 - 2014/9
N2 - Objective The effects of marked weight loss, induced by Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgeries, on insulin sensitivity, β-cell function and the metabolic response to a mixed meal were evaluated. Methods Fourteen nondiabetic insulin-resistant patients who were scheduled to undergo SG (n-=-7) or RYGB (n-=-7) procedures completed a hyperinsulinemic- euglycemic clamp procedure and a mixed-meal tolerance test before surgery and after losing ∼20% of their initial body weight. Results Insulin sensitivity (insulin-stimulated glucose disposal during a clamp procedure), oral glucose tolerance (postprandial plasma glucose area under the curve), and β-cell function (insulin secretion in relationship to insulin sensitivity) improved after weight loss, and were not different between surgical groups. The metabolic response to meal ingestion was similar after RYGB or SG, manifested by rapid delivery of ingested glucose into the systemic circulation and a large early postprandial increase in plasma glucose, insulin, and C-peptide concentrations in both groups. Conclusions When matched on weight loss, RYGB and SG surgeries result in similar improvements in the two major factors involved in regulating plasma glucose homeostasis, insulin sensitivity and β-cell function in obese people without diabetes.
AB - Objective The effects of marked weight loss, induced by Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgeries, on insulin sensitivity, β-cell function and the metabolic response to a mixed meal were evaluated. Methods Fourteen nondiabetic insulin-resistant patients who were scheduled to undergo SG (n-=-7) or RYGB (n-=-7) procedures completed a hyperinsulinemic- euglycemic clamp procedure and a mixed-meal tolerance test before surgery and after losing ∼20% of their initial body weight. Results Insulin sensitivity (insulin-stimulated glucose disposal during a clamp procedure), oral glucose tolerance (postprandial plasma glucose area under the curve), and β-cell function (insulin secretion in relationship to insulin sensitivity) improved after weight loss, and were not different between surgical groups. The metabolic response to meal ingestion was similar after RYGB or SG, manifested by rapid delivery of ingested glucose into the systemic circulation and a large early postprandial increase in plasma glucose, insulin, and C-peptide concentrations in both groups. Conclusions When matched on weight loss, RYGB and SG surgeries result in similar improvements in the two major factors involved in regulating plasma glucose homeostasis, insulin sensitivity and β-cell function in obese people without diabetes.
UR - http://www.scopus.com/inward/record.url?scp=84906939587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906939587&partnerID=8YFLogxK
U2 - 10.1002/oby.20803
DO - 10.1002/oby.20803
M3 - Article
C2 - 24891156
AN - SCOPUS:84906939587
SN - 1930-7381
VL - 22
SP - 2026
EP - 2031
JO - Obesity
JF - Obesity
IS - 9
ER -