Maternal selenium nutrition and neonatal immune system development

Maggie L. Dylewski; Andrea M. Mastro; Mary Frances Picciano

doi:10.1159/000063088

Maternal selenium nutrition and neonatal immune system development

Maggie L. Dylewski, Andrea M. Mastro, Mary Frances Picciano

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We evaluated the impact of dietary selenium intake on neonatal immune cell differentiation and function. A low selenium intake during pregnancy and lactation produced reductions in maternal plasma selenium (33%, p =0.0001), milk selenium (36%, p =0.001), and corresponding neonatal plasma selenium (47%, p =0.008). Thymocytes from neonates receiving low-selenium milk showed an impaired activation in vitro (p =0.001). The percentages of CD8 cytotoxic T cells (p =0.03), CD2 T cells (p =0.09), panB cells ( =0.02), and natural killer cells (p =0.07) were all decreased in neonates nursed by mothers fed a low-selenium diet. The results indicate that maternal selenium intake impacts neonatal selenium status which in turn influences the neonatal immune system development.

Original language	English (US)
Pages (from-to)	122-127
Number of pages	6
Journal	Biology of the Neonate
Volume	82
Issue number	2
DOIs	https://doi.org/10.1159/000063088
State	Published - Aug 28 2002

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Developmental Biology

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10.1159/000063088

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abstract = "We evaluated the impact of dietary selenium intake on neonatal immune cell differentiation and function. A low selenium intake during pregnancy and lactation produced reductions in maternal plasma selenium (33%, p =0.0001), milk selenium (36%, p =0.001), and corresponding neonatal plasma selenium (47%, p =0.008). Thymocytes from neonates receiving low-selenium milk showed an impaired activation in vitro (p =0.001). The percentages of CD8 cytotoxic T cells (p =0.03), CD2 T cells (p =0.09), panB cells ( =0.02), and natural killer cells (p =0.07) were all decreased in neonates nursed by mothers fed a low-selenium diet. The results indicate that maternal selenium intake impacts neonatal selenium status which in turn influences the neonatal immune system development.",

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AU - Picciano, Mary Frances

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Maternal selenium nutrition and neonatal immune system development

Abstract

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