TY - JOUR
T1 - Maternal Weight and Body Composition during Pregnancy Are Associated with Placental and Birth Weight in Rural Bangladesh1,2
AU - Gernand, Alison D.
AU - Christian, Parul
AU - Paul, Rina Rani
AU - Shaikh, Saijuddin
AU - Labrique, Alain B.
AU - Schulze, Kerry J.
AU - Shamim, Abu Ahmed
AU - West, Keith P.
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Placental growth is a strong predictor of fetal growth, but little is known about maternal predictors of placental growth in malnourished populations. Our objective was to investigate in a prospective study the associations of maternal weight and body composition [total body water (TBW) estimated by bioelectrical impedance and fat and fat-free mass derived from upper arm fat and muscle areas (UAFA, UAMA)] and changes in these with placental and birth weights. Within a cluster- randomized trial of maternal micronutrient supplementation, a subsample of 350 women was measured 3 times across gestation. Longitudinal analysis was used to examine independent associations of;10-wk measurements and;10-20wk and;20-32wk changes with birth outcomes. Weight, TBW, and UAMA, but not UAFA, at;10wk were each positively and independently associated with placental weight and birth weight (P < 0.05). Of the maternal;10-20wk changes in measurements, only TBW change and placental weight, and maternal weight and birth weight were positively associated (P < 0.05). Gains in weight, TBW, and UAMA from 20 to 32wk were positively and UAFA gain was negatively associated with placental weight (P # 0.01). Gains in weight and UAMA from 20 to 32wk were positively associated with birth weight (P # 0.01). Overall, higher maternal weight and measures of fat-free mass at;10wk gestation and gains from 20 to 32wk are independently associated with higher placental and birth weight.
AB - Placental growth is a strong predictor of fetal growth, but little is known about maternal predictors of placental growth in malnourished populations. Our objective was to investigate in a prospective study the associations of maternal weight and body composition [total body water (TBW) estimated by bioelectrical impedance and fat and fat-free mass derived from upper arm fat and muscle areas (UAFA, UAMA)] and changes in these with placental and birth weights. Within a cluster- randomized trial of maternal micronutrient supplementation, a subsample of 350 women was measured 3 times across gestation. Longitudinal analysis was used to examine independent associations of;10-wk measurements and;10-20wk and;20-32wk changes with birth outcomes. Weight, TBW, and UAMA, but not UAFA, at;10wk were each positively and independently associated with placental weight and birth weight (P < 0.05). Of the maternal;10-20wk changes in measurements, only TBW change and placental weight, and maternal weight and birth weight were positively associated (P < 0.05). Gains in weight, TBW, and UAMA from 20 to 32wk were positively and UAFA gain was negatively associated with placental weight (P # 0.01). Gains in weight and UAMA from 20 to 32wk were positively associated with birth weight (P # 0.01). Overall, higher maternal weight and measures of fat-free mass at;10wk gestation and gains from 20 to 32wk are independently associated with higher placental and birth weight.
UR - http://www.scopus.com/inward/record.url?scp=84869134328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869134328&partnerID=8YFLogxK
U2 - 10.3945/jn.112.163634
DO - 10.3945/jn.112.163634
M3 - Article
C2 - 22990469
AN - SCOPUS:84869134328
SN - 0022-3166
VL - 142
SP - 2010
EP - 2016
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 11
ER -