Mathematical model of sarcoidosis

Wenrui Hao, Elliott D. Crouser, Avner Friedman

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on lung tissue of patients. No current model of sarcoidosis exists. In this paper we develop a mathematical model on the dynamics of the disease in the lung and use patients' lung tissue data to validate the model. The model is used to explore potential treatments.

Original languageEnglish (US)
Pages (from-to)16065-16070
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number45
StatePublished - Nov 11 2014

All Science Journal Classification (ASJC) codes

  • General


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