Mathematical modeling for immunocolloid labeling

C. Raymond, P. Milewski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

For many biological applications, it is becoming increasingly important to extend imaging capabilities to simultaneously identify multiple molecular species in order to gain insight into the structural and functional elements of cells. A key part of this drive is the ability to rationally optimize various labeling techniques, which in turn requires an understanding of the basic physical processes operating during the labeling process, and how these processes interact. The kinetics of the immunocolloid labeling process are typically modeled using a Langmuir kinetic equation [1]. However, very different behavior which can not be explained by a Langmuir-type model has been noted in certain experiments [2], [3]. We develop a mathematical model for the labeling process which exhibits these two behaviors in different parameter limits, gives some insight into how to optimize the labeling process, and can easily be extended to more complicated situations.

Original languageEnglish (US)
Title of host publication2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004
EditorsM. Laudon, B. Romanowicz
Pages155-157
Number of pages3
StatePublished - 2004
Event2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004 - Boston, MA, United States
Duration: Mar 7 2004Mar 11 2004

Publication series

Name2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004
Volume1

Other

Other2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004
Country/TerritoryUnited States
CityBoston, MA
Period3/7/043/11/04

All Science Journal Classification (ASJC) codes

  • General Engineering

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