Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22-37 glycopeptide domain presenting the full N-linked dodecasaccharide

Bin Wu; Zhongping Tan; Gong Chen; Jiehao Chen; Zihao Hua; Qian Wan; Krishnakumar Ranganathan; Samuel J. Danishefsky

doi:10.1016/j.tetlet.2006.09.050

Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22-37 glycopeptide domain presenting the full N-linked dodecasaccharide

Bin Wu
, Zhongping Tan
, Gong Chen
, Jiehao Chen
, Zihao Hua
, Qian Wan
, Krishnakumar Ranganathan
, Samuel J. Danishefsky

Chemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A synthesis of EPO 22-37 glycopeptide (1), presenting the N-linked dodecasaccharide of erythropoietin, is described.

Original language	English (US)
Pages (from-to)	8009-8011
Number of pages	3
Journal	Tetrahedron Letters
Volume	47
Issue number	46
DOIs	https://doi.org/10.1016/j.tetlet.2006.09.050
State	Published - Nov 13 2006

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2006.09.050

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@article{7d71ef14260c4d29a5f2b330ae53fff0,

title = "Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22-37 glycopeptide domain presenting the full N-linked dodecasaccharide",

abstract = "A synthesis of EPO 22-37 glycopeptide (1), presenting the N-linked dodecasaccharide of erythropoietin, is described.",

author = "Bin Wu and Zhongping Tan and Gong Chen and Jiehao Chen and Zihao Hua and Qian Wan and Krishnakumar Ranganathan and Danishefsky, \{Samuel J.\}",

note = "Funding Information: This work was supported by the NIH (CA28824 to S.J.D.). We thank Dr. George Sukenick, Ms. Sylvi Rusli, and Ms. Hui Fang of the Sloan-Kettering Institute{\textquoteright}s NMR core facility for mass spectral and NMR spectroscopic analysis (SKI core Grant No. CA02848). Postdoctoral fellowship support is gratefully acknowledged by B.W. (New York State Department of Health, New York State Breast Cancer Research and Education Fund). ",

year = "2006",

month = nov,

day = "13",

doi = "10.1016/j.tetlet.2006.09.050",

language = "English (US)",

volume = "47",

pages = "8009--8011",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "46",

}

TY - JOUR

T1 - Mature homogeneous erythropoietin building blocks by chemical synthesis

T2 - the EPO 22-37 glycopeptide domain presenting the full N-linked dodecasaccharide

AU - Wu, Bin

AU - Tan, Zhongping

AU - Chen, Gong

AU - Chen, Jiehao

AU - Hua, Zihao

AU - Wan, Qian

AU - Ranganathan, Krishnakumar

AU - Danishefsky, Samuel J.

N1 - Funding Information: This work was supported by the NIH (CA28824 to S.J.D.). We thank Dr. George Sukenick, Ms. Sylvi Rusli, and Ms. Hui Fang of the Sloan-Kettering Institute’s NMR core facility for mass spectral and NMR spectroscopic analysis (SKI core Grant No. CA02848). Postdoctoral fellowship support is gratefully acknowledged by B.W. (New York State Department of Health, New York State Breast Cancer Research and Education Fund).

PY - 2006/11/13

Y1 - 2006/11/13

N2 - A synthesis of EPO 22-37 glycopeptide (1), presenting the N-linked dodecasaccharide of erythropoietin, is described.

AB - A synthesis of EPO 22-37 glycopeptide (1), presenting the N-linked dodecasaccharide of erythropoietin, is described.

UR - https://www.scopus.com/pages/publications/33749520608

UR - https://www.scopus.com/pages/publications/33749520608#tab=citedBy

U2 - 10.1016/j.tetlet.2006.09.050

DO - 10.1016/j.tetlet.2006.09.050

M3 - Article

AN - SCOPUS:33749520608

SN - 0040-4039

VL - 47

SP - 8009

EP - 8011

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22-37 glycopeptide domain presenting the full N-linked dodecasaccharide

Abstract

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