McCune-Albright Syndrome: Long-term Follow-up

Peter Lee, Cornelis Van Dop, Claude J. Migeon

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132 Scopus citations


This article describes clinical follow-up of 15 patients—13 females and two males—with McCune-Albright syndrome. Osseous fractures occurred only during childhood, while hearing impairment due to temporal bone involvement occurred in four of six adults. Four females with precocious puberty had final heights that were not different from the mean for normal females; they eventually developed regular menses, and two had children. Persistent hyperthyroidism requiring ablative therapy occurred in three subjects, while hypophosphatemia occurred in three subjects. The protean manifestations of this disorder suggest that it results from a basic defect of cellular regulation. We postulate that its varied endocrine abnormalities result from altered regulation of intracellular cyclic adenosine monophosphate effects.

Original languageEnglish (US)
Pages (from-to)2980-2984
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Issue number21
StatePublished - Dec 5 1986

All Science Journal Classification (ASJC) codes

  • General Medicine


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