MD simulations of the dsRBP DGCR8 reveal correlated motions that may aid pri-miRNA binding

Keyphrases

• Molecular Dynamics Simulation 100%
• DGCR8 100%
• Correlated Motion 100%
• RNA Binding 50%
• MicroRNA 25%
• Messenger RNA (mRNA) 25%
• In Vitro Study 25%
• Gene Regulation 25%
• Separation Distance 25%
• Deregulation 25%
• In Tandem 25%
• Well-ordered 25%
• Interfacial Interaction 25%
• C-terminus 25%
• Two-component Domains 25%
• Linker 25%
• Antiviral Response 25%
• Drosha 25%
• RNase III 25%
• Binding Mode 25%
• Binding Surface 25%
• Base Pairing 25%
• Domain Interface 25%
• Heterogeneous Structure 25%
• Linker Region 25%
• Nuclear Maturation 25%
• Primary microRNA 25%

Biochemistry, Genetics and Molecular Biology

• MicroRNA 100%
• Motion 100%
• RNA Binding 66%
• Conformation 33%
• Surface Property 33%
• Enzyme 33%
• Ribonuclease 33%
• C-Terminus 33%
• Crystal Structure 33%
• In Vitro Study 33%
• Gene Control 33%
• Messenger RNA 33%
• Maturation 33%
• Drosha 33%

Immunology and Microbiology

• RNA Binding 100%
• Motion 100%
• Surface Property 50%
• Carboxy Terminal Sequence 50%
• Crystal Structure 50%
• Conformation 50%
• Maturation 50%
• Gene Control 50%