Measures of injury severity and prediction of acute traumatic brain injury outcomes

Paul B. Perrin, Janet P. Niemeier, Jean Luc Mougeot, Charles H. Vannoy, Mark A. Hirsch, John A. Watts, Whitney Rossman, Lori M. Grafton, Tami D. Guerrier, Rashmi Pershad, Carla A. Kingsbury, Sheri W. Bartel, Marybeth P. Whitney

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Objective: To examine the comparative efficacy of 3 common measures of traumatic brain injury (TBI) severity for predicting inpatient outcomes upon hospital discharge. Setting: Acute brain injury rehabilitation unit at level 1 trauma center. Participants: 100 patients with TBI. Design: Retrospective analysis of injury severity, demographic, and outcome data. Main Measures: Glasgow Coma Scale (GCS) at admission, time to follow commands (TTC), duration of posttraumatic amnesia (PTA), and Functional Independence Measure at hospital discharge. Results: A hierarchal multiple regression revealed that duration of PTA was a significant and powerful unique predictor of Functional Independence Measure scores at discharge (ß = -0.46, P = .001), while TTC (ß = 0.26, P = .056) and GCS (ß = 0.16, P = .143) were not. These effects were present even after controlling for age, gender, educational level, racial/ethnic minority status, cause of injury, history of substance abuse, and neurosurgical intervention. Conclusion: Although clinicians often use GCS scores and TTC when assessing acute TBI severity and during treatment formulation, this study provides evidence that duration of PTA may be a more meaningful predictor of patients' functional levels at discharge.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalJournal of Head Trauma Rehabilitation
Issue number2
StatePublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology


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