Measuring mild cognitive impairment in patients with Parkinson's disease

Connie Marras, Melissa J. Armstrong, Christopher A. Meaney, Susan Fox, Brandon Rothberg, William Reginold, David F. Tang-Wai, David Gill, Paul J. Eslinger, Cindy Zadikoff, Nancy Kennedy, Fred J. Marshall, Mark Mapstone, Kelvin L. Chou, Carol Persad, Irene Litvan, Benjamin T. Mast, Adam T. Gerstenecker, Sandra Weintraub, Sarah Duff-Canning

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


We examined the frequency of Parkinson disease with mild cognitive impairment (PD-MCI) and its subtypes and the accuracy of 3 cognitive scales for detecting PD-MCI using the new criteria for PD-MCI proposed by the Movement Disorders Society. Nondemented patients with Parkinson's disease completed a clinical visit with the 3 screening tests followed 1 to 3 weeks later by neuropsychological testing. Of 139 patients, 46 met Level 2 Task Force criteria for PD-MCI when impaired performance was based on comparisons with normative scores. Forty-two patients (93%) had multi-domain MCI. At the lowest cutoff levels that provided at least 80% sensitivity, specificity was 44% for the Montreal Cognitive Assessment and 33% for the Scales for Outcomes in Parkinson's Disease-Cognition. The Mini-Mental State Examination could not achieve 80% sensitivity at any cutoff score. At the highest cutoff levels that provided specificity of at least 80%, sensitivities were low (≤44%) for all tests. When decline from estimated premorbid levels was considered evidence of cognitive impairment, 110 of 139 patients were classified with PD-MCI, and 103 (94%) had multi-domain MCI. We observed dramatic differences in the proportion of patients who had PD-MCI using the new Level 2 criteria, depending on whether or not decline from premorbid level of intellectual function was considered. Recommendations for methods of operationalizing decline from premorbid levels constitute an unmet need. Among the 3 screening tests examined, none of the instruments provided good combined sensitivity and specificity for PD-MCI. Other tests recommended by the Task Force Level 1 criteria may represent better choices, and these should be the subject of future research.

Original languageEnglish (US)
Pages (from-to)626-633
Number of pages8
JournalMovement Disorders
Issue number5
StatePublished - Apr 15 2013

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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