Mechanism of cytokine modulation of epithelial tight junction barrier

Rana Al-Sadi, Michel Boivin, Thomas Ma

Research output: Contribution to journalArticlepeer-review

488 Scopus citations


Cytokines play a crucial role in the modulation of inflammatory response in the gastrointestinal tract. Proinflammatory cytokines including tumor necrosis factor-α, interferon-γ, interleukin-1β (IL-1β), and interleukin-12 are essential in mediating the inflammatory response, while anti-inflammatory cytokines including interleukin-10 and transforming growth factor-β are important in the attenuation or containment of inflammatory process. It is increasingly recognized that cytokines have an important physiological and pathological effect on intestinal tight junction (TJ) barrier. Consistent with their known proinflammatory activities, pro-inflammatory cytokines cause a disturbance in intestinal TJ barrier, allowing increased tissue penetration of luminal antigens. Recent studies indicate that the inhibition of cytokine induced increase in intestinal TJ permeability has an important protective effect against intestinal mucosal damage and development of intestinal inflammation. In this review, the effects of various pro-inflammatory and anti-inflammatory cytokines on intestinal TJ barrier and the progress into the mechanisms that mediate the cytokine modulation of intestinal TJ barrier are reviewed.

Original languageEnglish (US)
Pages (from-to)2765-2778
Number of pages14
JournalFrontiers in Bioscience
Issue number7
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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