Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium

Sten Lyager Nielsen; Hans Nygaard; Lars Mandrup; Arnold A. Fontaine; J. Michael Hasenkam; Shengqui He; Ajit P. Yoganathan

doi:10.1115/1.1500741

Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium

Sten Lyager Nielsen
, Hans Nygaard
, Lars Mandrup
, Arnold A. Fontaine
, J. Michael Hasenkam
, Shengqui He
, Ajit P. Yoganathan

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.

Original language	English (US)
Pages (from-to)	596-608
Number of pages	13
Journal	Journal of Biomechanical Engineering
Volume	124
Issue number	5
DOIs	https://doi.org/10.1115/1.1500741
State	Published - Oct 2002

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Physiology (medical)

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Nielsen, S. L., Nygaard, H., Mandrup, L., Fontaine, A. A., Hasenkam, J. M., He, S., & Yoganathan, A. P. (2002). Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium. Journal of Biomechanical Engineering, 124(5), 596-608. https://doi.org/10.1115/1.1500741

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title = "Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium",

abstract = "Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.",

author = "Nielsen, \{Sten Lyager\} and Hans Nygaard and Lars Mandrup and Fontaine, \{Arnold A.\} and Hasenkam, \{J. Michael\} and Shengqui He and Yoganathan, \{Ajit P.\}",

year = "2002",

month = oct,

doi = "10.1115/1.1500741",

language = "English (US)",

volume = "124",

pages = "596--608",

journal = "Journal of Biomechanical Engineering",

issn = "0148-0731",

publisher = "American Society of Mechanical Engineers (ASME)",

number = "5",

}

Nielsen, SL, Nygaard, H, Mandrup, L, Fontaine, AA, Hasenkam, JM, He, S & Yoganathan, AP 2002, 'Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium', Journal of Biomechanical Engineering, vol. 124, no. 5, pp. 596-608. https://doi.org/10.1115/1.1500741

Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium. / Nielsen, Sten Lyager; Nygaard, Hans; Mandrup, Lars et al.
In: Journal of Biomechanical Engineering, Vol. 124, No. 5, 10.2002, p. 596-608.

Research output: Contribution to journal › Article › peer-review

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AU - He, Shengqui

AU - Yoganathan, Ajit P.

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N2 - Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.

AB - Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.

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Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium

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