Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

Volker Spindler; Rüdiger Eming; Enno Schmidt; Masayuki Amagai; Sergei Grando; Marcel F. Jonkman; Andrew P. Kowalczyk; Eliane J. Müller; Aimee S. Payne; Carlo Pincelli; Animesh A. Sinha; Eli Sprecher; Detlef Zillikens; Michael Hertl; Jens Waschke

doi:10.1016/j.jid.2017.06.022

Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

Volker Spindler, Rüdiger Eming, Enno Schmidt, Masayuki Amagai, Sergei Grando, Marcel F. Jonkman, Andrew P. Kowalczyk, Eliane J. Müller, Aimee S. Payne, Carlo Pincelli, Animesh A. Sinha, Eli Sprecher, Detlef Zillikens, Michael Hertl, Jens Waschke

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

Original language	English (US)
Pages (from-to)	32-37
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.jid.2017.06.022
State	Published - Jan 2018

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2017.06.022

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Spindler, V., Eming, R., Schmidt, E., Amagai, M., Grando, S., Jonkman, M. F., Kowalczyk, A. P., Müller, E. J., Payne, A. S., Pincelli, C., Sinha, A. A., Sprecher, E., Zillikens, D., Hertl, M., & Waschke, J. (2018). Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. Journal of Investigative Dermatology, 138(1), 32-37. https://doi.org/10.1016/j.jid.2017.06.022

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title = "Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus",

abstract = "The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.",

author = "Volker Spindler and R{\"u}diger Eming and Enno Schmidt and Masayuki Amagai and Sergei Grando and Jonkman, {Marcel F.} and Kowalczyk, {Andrew P.} and M{\"u}ller, {Eliane J.} and Payne, {Aimee S.} and Carlo Pincelli and Sinha, {Animesh A.} and Eli Sprecher and Detlef Zillikens and Michael Hertl and Jens Waschke",

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year = "2018",

month = jan,

doi = "10.1016/j.jid.2017.06.022",

language = "English (US)",

volume = "138",

pages = "32--37",

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AU - Spindler, Volker

AU - Eming, Rüdiger

AU - Schmidt, Enno

AU - Amagai, Masayuki

AU - Grando, Sergei

AU - Jonkman, Marcel F.

AU - Kowalczyk, Andrew P.

AU - Müller, Eliane J.

AU - Payne, Aimee S.

AU - Pincelli, Carlo

AU - Sinha, Animesh A.

AU - Sprecher, Eli

AU - Zillikens, Detlef

AU - Hertl, Michael

AU - Waschke, Jens

PY - 2018/1

Y1 - 2018/1

N2 - The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

AB - The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

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JO - Journal of Investigative Dermatology

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Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

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