Mechanisms of cisplatin nephrotoxicity

Ronald P. Miller; Raghu K. Tadagavadi; Ganesan Ramesh; William Brian Reeves

doi:10.3390/toxins2112490

Mechanisms of cisplatin nephrotoxicity

Ronald P. Miller, Raghu K. Tadagavadi, Ganesan Ramesh, William Brian Reeves

Research output: Contribution to journal › Review article › peer-review

1312 Scopus citations

Abstract

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

Original language	English (US)
Pages (from-to)	2490-2518
Number of pages	29
Journal	Toxins
Volume	2
Issue number	11
DOIs	https://doi.org/10.3390/toxins2112490
State	Published - Nov 2010

All Science Journal Classification (ASJC) codes

Toxicology
Health, Toxicology and Mutagenesis

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10.3390/toxins2112490

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title = "Mechanisms of cisplatin nephrotoxicity",

abstract = "Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.",

author = "Miller, {Ronald P.} and Tadagavadi, {Raghu K.} and Ganesan Ramesh and Reeves, {William Brian}",

year = "2010",

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AU - Miller, Ronald P.

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AU - Ramesh, Ganesan

AU - Reeves, William Brian

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N2 - Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

AB - Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

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JF - Toxins

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Mechanisms of cisplatin nephrotoxicity

Abstract

All Science Journal Classification (ASJC) codes

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