Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Emery H. Bresnick; Kyle J. Hewitt; Charu Mehta; Sunduz Keles; Robert F. Paulson; Kirby D. Johnson

doi:10.1242/dev.151423

Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Emery H. Bresnick, Kyle J. Hewitt, Charu Mehta, Sunduz Keles, Robert F. Paulson, Kirby D. Johnson

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

Original language	English (US)
Article number	dev151423
Journal	Development (Cambridge)
Volume	145
Issue number	1
DOIs	https://doi.org/10.1242/dev.151423
State	Published - Jan 2018

All Science Journal Classification (ASJC) codes

Molecular Biology
Developmental Biology

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title = "Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond",

abstract = "Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed {\textquoteleft}stress erythropoiesis{\textquoteright} to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.",

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AU - Keles, Sunduz

AU - Paulson, Robert F.

AU - Johnson, Kirby D.

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N2 - Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

AB - Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

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Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Abstract

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