Mechanisms of metastasis as related to receptor tyrosine kinases in small-cell lung cancer

Nazia F. Jafri, Patrick C. Ma, Gautam Maulik, Ravi Salgia

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Small-cell lung cancer (SCLC) is an aggressive, malignant neoplasm with a 5-year survival of less than 10%. This poor survival rate is related to a high propensity for recurrence and a high rate of metastases. Metastases initially occur in the lymph nodes and thereafter in other organs such as the lung itself, liver, adrenal glands, brain, bone, and bone marrow. The mechanisms of metastases have been better understood recently and are described in this review. Receptor tyrosine kinases (RTKs) have been identified as important therapeutic targets in non-smallcell lung cancer (such as the EGF-receptor). We have begun to identify RTKs in SCLC and have shown that c-Kit and c-Met are expressed and functional in SCLC. RTKs have also been shown to be important in the metastasis of cancer cells. The roles of RTKs in the mechanism of metastasis are detailed in this review, with special emphasis on downstream signal transduction from RTK signaling.

Original languageEnglish (US)
Pages (from-to)147-165
Number of pages19
JournalJournal of Environmental Pathology, Toxicology and Oncology
Issue number3
StatePublished - 2003

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis


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