Mechanisms of phospholipase C-regulated calcium entry

Gary S. Bird, Omar Aziz, Jean Philippe Lievremont, Barbara J. Wedel, Mohamed Trebak, Guillermo Vazquez, James W. Putney

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, store-operated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalCurrent Molecular Medicine
Issue number3
StatePublished - May 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology


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