Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

T. K. Said; R. C.B. Moraes; R. Sinha; D. Medina

doi:10.1186/bcr284

Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

T. K. Said, R. C.B. Moraes, R. Sinha, D. Medina

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.

Original language	English (US)
Pages (from-to)	122-133
Number of pages	12
Journal	Breast Cancer Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1186/bcr284
State	Published - 2001

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1186/bcr284

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title = "Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth",

abstract = "The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.",

author = "Said, {T. K.} and Moraes, {R. C.B.} and R. Sinha and D. Medina",

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AB - The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.

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Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

Abstract

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