Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Anthony C. Ruocco; John D. Medaglia; Jennifer R. Tinker; Hasan Ayaz; Evan M. Forman; Cory F. Newman; J. Michael Williams; Frank Gerard Hillary; Steven M. Platek; Banu Onaral; Douglas L. Chute

doi:10.1016/j.pscychresns.2009.12.001

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Anthony C. Ruocco, John D. Medaglia, Jennifer R. Tinker, Hasan Ayaz, Evan M. Forman, Cory F. Newman, J. Michael Williams, Frank Gerard Hillary, Steven M. Platek, Banu Onaral, Douglas L. Chute

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

Original language	English (US)
Pages (from-to)	233-236
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	181
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2009.12.001
State	Published - Mar 30 2010

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2009.12.001

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Ruocco, A. C., Medaglia, J. D., Tinker, J. R., Ayaz, H., Forman, E. M., Newman, C. F., Williams, J. M., Hillary, F. G., Platek, S. M., Onaral, B., & Chute, D. L. (2010). Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder. Psychiatry Research - Neuroimaging, 181(3), 233-236. https://doi.org/10.1016/j.pscychresns.2009.12.001

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AU - Forman, Evan M.

AU - Newman, Cory F.

AU - Williams, J. Michael

AU - Hillary, Frank Gerard

AU - Platek, Steven M.

AU - Onaral, Banu

AU - Chute, Douglas L.

PY - 2010/3/30

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Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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