Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Anthony C. Ruocco; John D. Medaglia; Jennifer R. Tinker; Hasan Ayaz; Evan M. Forman; Cory F. Newman; J. Michael Williams; Frank Gerard Hillary; Steven M. Platek; Banu Onaral; Douglas L. Chute

doi:10.1016/j.pscychresns.2009.12.001

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Anthony C. Ruocco
, John D. Medaglia
, Jennifer R. Tinker
, Hasan Ayaz
, Evan M. Forman
, Cory F. Newman
, J. Michael Williams
, Frank Gerard Hillary
, Steven M. Platek
, Banu Onaral
, Douglas L. Chute

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

Original language	English (US)
Pages (from-to)	233-236
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	181
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2009.12.001
State	Published - Mar 30 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2009.12.001

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Ruocco, A. C., Medaglia, J. D., Tinker, J. R., Ayaz, H., Forman, E. M., Newman, C. F., Williams, J. M., Hillary, F. G., Platek, S. M., Onaral, B., & Chute, D. L. (2010). Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder. Psychiatry Research - Neuroimaging, 181(3), 233-236. https://doi.org/10.1016/j.pscychresns.2009.12.001

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abstract = "Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.",

author = "Ruocco, \{Anthony C.\} and Medaglia, \{John D.\} and Tinker, \{Jennifer R.\} and Hasan Ayaz and Forman, \{Evan M.\} and Newman, \{Cory F.\} and Williams, \{J. Michael\} and Hillary, \{Frank Gerard\} and Platek, \{Steven M.\} and Banu Onaral and Chute, \{Douglas L.\}",

year = "2010",

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doi = "10.1016/j.pscychresns.2009.12.001",

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AU - Ruocco, Anthony C.

AU - Medaglia, John D.

AU - Tinker, Jennifer R.

AU - Ayaz, Hasan

AU - Forman, Evan M.

AU - Newman, Cory F.

AU - Williams, J. Michael

AU - Hillary, Frank Gerard

AU - Platek, Steven M.

AU - Onaral, Banu

AU - Chute, Douglas L.

PY - 2010/3/30

Y1 - 2010/3/30

N2 - Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

AB - Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

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SN - 0925-4927

VL - 181

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EP - 236

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

IS - 3

ER -

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Abstract

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