Medial temporal N-acetyl-aspartate in pediatric major depression

Frank P. MacMaster; Gregory J. Moore; Aileen Russell; Yousha Mirza; S. Preeya Taormina; Christian Buhagiar; David R. Rosenberg

doi:10.1016/j.pscychresns.2007.12.022

Medial temporal N-acetyl-aspartate in pediatric major depression

Frank P. MacMaster
, Gregory J. Moore
, Aileen Russell
, Yousha Mirza
, S. Preeya Taormina
, Christian Buhagiar
, David R. Rosenberg

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD). Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	164
Issue number	1
DOIs	https://doi.org/10.1016/j.pscychresns.2007.12.022
State	Published - Oct 31 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2007.12.022

Cite this

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AU - Russell, Aileen

AU - Mirza, Yousha

AU - Taormina, S. Preeya

AU - Buhagiar, Christian

AU - Rosenberg, David R.

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AB - The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD). Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability.

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Medial temporal N-acetyl-aspartate in pediatric major depression

Abstract

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